This spring when aid was cut and it was clear that preventable deaths were going to spike, I sent off $5k immediately to efforts to plug gaps, then sat down with my wife and talked about our budget and how we could donate a lot more than the 30% of my income I usually aim for.

I'm hoping to hit more like 40% or 50% this year - $50k or so. I think the global war on disease is important, we've made strides in it I'm enormously proud of, and the best of the programs that were cut are incredibly cost-effective.

I don't mind people doing clever math to reach counterintuitive conclusions about shrimp, but if your clever math only leads you to counterintuitive blog posts and never to save the lives of hundreds of people as cost-effectively as possible, I don't take you that seriously.

And if you do change your own life and your own habits to make the world much better - whether by saving the lives of hundreds of people or by inventing new medicines - then I take you very very seriously whatever the theoretical framework which moved you to do that.

Ultimately, the thing that matters the most to me is that everything good in the world is fragile and hard-fought and enormously important and enormously scarce and we can hand a better world down to our children, or burn it to the ground, and had better pick wisely.