I don't know who needs to hear this, but here goes. I apologize to all those who have sent me your life's work and didn't get a reply. Believe me, I know what it's like to dedicate oneself to a set of ideas, and pour all of one's blood, sweat, and tears into it. I know all about having an unconventional story to tell and finding it hard to get traction from the mainstream. I know the feeling when the idea GRABS you and demands you push it forward. But I get 500-700 new emails per day. I can barely get to the ones from my post-docs, students, collaborators, program officers, journal editors, and colleagues - people I have commitments to and promises to keep. There's a lot going on and the research and biomed roadmap are my main responsibilities. I simply do not get to see most of what I am sent by people with their favorite Theory Of Everything or brilliant idea (~20-30 of those per day); same with Tweets or replies - total chance if I see it or not. If you didn't get a reply, I almost certainly didn't have time to see it. It's no reflection on the quality of the work. Actually I'm sure that among the thousands of these are probably some real gems. But I do not have the time to sort those out. And many are outside my expertise anyway - from exorcisms to quantum theory, most have nothing to do with me or my knowledge base anyway. Oh and there's also the fact that I'm not allowed (for legal reasons) to look at anything unsolicited that isn't public information (e.g., a document and not a link to a preprint like OSF Preprints hosts). But regardless, to look at your big idea, I'd have to drop one of mine or my post-docs'. It's just simple math of 24 hours in a day. I'm sorry; I wish everyone had the opportunity to get qualified eyeballs on the product of their hard work. Oh and this is a fun pattern, it goes in stages... Stage 1 is a nice initial email - "I like your work, look at this, it's important". Stage 2 is still nice - "I'm sure you're busy, but this one really is good, not like the others, you have to make time to see this." Stage 3 is getting irritated: "You think you're too big to talk to me? What gives you the right to ignore this?". Stage 4 is cursing and various insults and profanity, mixed in with offers to collaborate (those are my favorite). Stage 5 is full-out threats (not all of them get to stage 5, but enough). So for those who stopped at stage 1 or 2, thank you for being rational, I appreciate it. For those that didn't, maybe I'll connect you to each other and you can thrash it out without my involvement... Also, if you're at stage 4-5, keep it up - your emails are saved for a book I'll publish someday - no commentary needed from me, just email after email, they speak for themselves. I envision huge sales for this one - it's some wild, wild stuff. Maybe I'll get an artist to illustrate them.